Microbiome, DNA repair and Exosomes as promising photoageing solutions

Recent advancements highlight the microbiome's potential in addressing ageing and photoageing. [1] Research shows that “skin microbiota plays a key role in skin homeostasis. It has also been demonstrated that bacterial molecules can block UV rays or reverse their harmful effects. Microbial-based active sunscreen compounds have massive potential for use as next-generation photoprotection products." [2] Dr. Marie Drago, founder of Gallinée, further explains, “Researchers are currently studying the role of microbiome in melanogenesis. It seems that a healthy microbiome could regulate melanogenesis.”

Beyond individual innovations, biotech companies are creating microbiome-boosting ingredients that act as SPF boosters, leveraging good bacteria to strengthen the skin’s defenses against sun damage. David Suissa, CEO and founder of BYOME LABS, emphasizes the potential of these solutions: “Cosmetic formulations enriched with pre-, pro-, or postbiotics can help restore the microbiome's balance. They support beneficial microorganisms, strengthen the skin barrier, and enhance the skin's ability to defend against oxidative stress and external aggressions.” (See the full interview with David Suissa in the expert Q&A about photoageing and microbiome)

It is scientifically proven that UV causes DNA damage via oxidative stress, and the impaired repair of these lesions plays a key role in producing photodamaged skin. [3] New research revealed that ingredients like microalgae defend against UV radiation by repairing DNA, producing antioxidants, and creating UV-filtering compounds, also known as "microbial sunscreens." [4] These natural defenses make microalgae promising ingredients for ecofriendly sunscreens in the cosmetic industry. "Recent research indicates that including DNA-repair enzymes in traditional sunscreens gives a more effective alternative to prevent photoageing caused by sun damage. Combining them with topically applied antioxidants is a good way to enhance this impact further.” [4]

New solutions targeting skin cell DNA repair are entering the market to further protect the skin against photoageing and bring a new wealth of solutions to skincare.

Emerging research highlights the promising role of exosomes in addressing photoageing, aligning seamlessly with the growing prejuvenation trend, which focuses on preventative and proactive skincare [5]. These tiny extracellular vesicles play a crucial role in intercellular communication, delivering bioactive molecules such as proteins, lipids, and nucleic acids to repair damaged cells and promote regeneration. In the context of skincare, exosomes have shown remarkable potential to boost collagen synthesis, reduce oxidative stress, and enhance the skin's natural repair mechanisms, making them a powerful tool for targeting the visible and underlying effects of photoageing. As research progresses, exosomes are poised to become a cornerstone of innovative anti-ageing solutions, offering precise, science-backed approaches for maintaining youthful, healthy skin. [6]